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This book provides a comprehensive overview of the current progress in muscle contraction and cell motility research. It discusses structural, mechanical, and biochemical characteristics of skeletal, cardiac, and smooth muscles, and cell motility. The experimental objects of the studies described in this volume extend from humans to molecules. A distinct feature of this volume is that, in some chapters, evidence against the textbook view is presented, showing how well-established dogma can be denied by an unexpected discovery. This book is as interesting as it is informative for general readers and young scientists alike, and it is sure to inspire both to challenge the enticing mysteries that still remain in this exciting research field.